MICROBIAL BIOCHEMISTRY AND MOLECULAR BIOLOGY (3)
Prerequisites: 16:115:511,512, or equivalents; 16:681:521.
Survey of the biochemical activities unique to microorganisms emphasizing the similarities and differences between prokaryotic and eukaryotic organisms; consideration of the genetic regulation and practical importance of these biochemical capabilities. Topics include methanogenesis, toxins, biodegradation, microbial transformations, and secondary metabolites.

INDUSTRIAL MICROBIOLOGY (3)
Prerequisites: 16:681:501, one year of organic chemistry.
Industrial applications of microorganisms, including production of chemicals and antibiotics, transformations, product stability, protection from deterioration, impact on environment, continuous fermentations, and waste disposal.

INTRODUCTION TO MOLECULAR MEDICINE (3)
Application of molecular and cell biology to a wide variety of human diseases; recent advances in understanding basic mechanisms.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (4.5)
Bacteria and human cells in culture. Biochemical correlations. Comparative cytology, metabolism, genetics, regulation of protein synthesis and enzyme function, immunology, virology, and medical microbiology. Principles governing mechanisms of human disease emphasized.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY LABORATORY (2.5)
Corequisite: 16:681:544.
Experiments in the isolation, identification, and growth kinetics of bacteria; bioassay methods; organelle biogenesis; human karyotyping; diagnostic bacteriology; immunological methods; animal cell culture and virology. Concepts and techniques relevant to medical problems emphasized.

MOLECULAR VIROLOGY (3)
Prerequisite: 16:681:501 or equivalent.
Detailed consideration of fundamental physical-chemical properties, schemes of classification, genetics, and modes of replication of selected animal viruses.

MICROBIAL ECOLOGY AND BIODIVERSITY (4)
Barkay. Lec. 3 hrs., lab. 3 hrs. Prerequisite: 16:681:501.
Qualitative and quantitative methods for the study of microbial communities. Ecological determinants. Characteristics of aquatic and terrestrial ecosystems. Biogeochemical cycles and energy flow. Microbial interactions and community structure.

FUNDAMENTALS OF MOLECULAR GENETICS (3)
Prerequisites: Genetics; 16:115:511,512.
Basic mechanisms of information storage in and retrieval from nucleic acids; organization of prokaryotic and eukaryotic genomes; mechanisms of DNA replication; transposable genetic elements; transcriptional and translational control of gene expression. Designed to provide necessary background for advanced molecular genetics courses.

CANCER MOLECULAR BIOLOGY (3)
Emphasis on the molecular, cellular, and genetic basis for cancer. Oncogenes and tumor suppressor genes. Signal transduction and cell cycle control in cancer cells. Metastasis. Diagnosis and therapy. Recent understanding of the molecular basis of selected human cancers. Lectures and critical discussion of the current literature.

TEACHING TECHNIQUES IN MICROBIOLOGY AND MOLECULAR GENETICS (2,2)
Prerequisite: Open only to matriculated students in the graduate program in microbiology and molecular genetics.
Guidance and practical experience in the teaching of microbiology and molecular genetics.

LABORATORY ROTATION IN MICROBIOLOGY AND MOLECULAR GENETICS (2,2,2,2)
Prerequisite: Written approval of program director. Open only to matriculated students in the graduate program.Half-term research projects of interest to the student in faculty laboratories

INDEPENDENT STUDIES IN MICROBIOLOGY AND MOLECULAR BIOLOGY (BA)
Prerequisites: Permission of faculty adviser and program director.
Library research project normally leading to a nonthesis essay for master’s degree candidates.

SEMINAR IN MOLECULAR GENETICS AND MICROBIAL PHYSIOLOGY (1)
Informal critical description and discussion of current literature and concepts.

SEMINAR IN VIROLOGY, IMMUNOLOGY, AND PATHOGENIC MICROBIOLOGY (1)
The Application of Fungal Systems to Molecular and Cellular Biology
Informal critical description and discussion of current literature and concepts.

SEMINAR IN VIROLOGY, IMMUNOLOGY, AND PATHOGENIC MICROBIOLOGY (1)
Informal critical description and discussion of current literature and concepts

SEMINAR IN APPLIED, ENVIRONMENTAL, AND INDUSTRIAL MICROBIOLOGY (1,1)
Informal critical description and discussion of current literature and concepts.

SEMINAR IN COMPUTATIONAL MOLECULAR BIOLOGY (1,1)
Recent advances in computational molecular biology selected from the following areas: genomics, bioinformatics, structural biology, image analysis, pattern formation, and molecular evolution.

16:681:701
702